Structure via PubChem · Public domain (PubChem)
alisporivir
Sign in to saveAlso known as DEB025
Alisporivir (INN), or Debio 025, DEB025, (or UNIL-025) is a cyclophilin inhibitor. Its structure is reminiscent of and synthesized from ciclosporin.
In the Vinony graph
Vinony's link graph records 3 inbound references to alisporivir, and connects out to Japan, digital object identifier and chemical formula.
It sits within the topics Antiviral drugs, Chemical pages without DrugBank identifier and Drugboxes which contain changes to verified fields.
Vinony links it to 7 Wikipedia language editions.
Chemical data
- Formula
- C63H113N11O12
- Molecular weight
- 1216.6 g/mol
- IUPAC name
- (3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-25,30-diethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,27,28-nonamethyl-6,9,18-tris(2-methylpropyl)-3,21,24-tri(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
- SMILES
- CC[C@H]1C(=O)N([C@@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)C(C)C)CC)C)C
- InChIKey
- OLROWHGDTNFZBH-XEMWPYQTSA-N
- XLogP
- 7.9
- Polar surface area
- 279 Ų
- H-bond donors
- 5
- H-bond acceptors
- 12
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Protein
- Indications
- hepatitis C virus infection, chronic hepatitis C virus infection, liver disease, COVID-19
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 1215.857
Show 4 more facts
- chemical formula
- C₆₃H₁₁₃N₁₁O₁₂
- canonical SMILES
- CCC1C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)C(C)C)CC)C)C
- isomeric SMILES
- CC[C@H]1C(=O)N([C@@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)C(C)C)CC)C)C
- World Health Organisation international non-proprietary name
- alisporivir
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Alisporivir (INN), or Debio 025, DEB025, (or UNIL-025) is a cyclophilin inhibitor. Its structure is reminiscent of and synthesized from ciclosporin.
It inhibits cyclophilin A. Alisporivir is not immunosuppressive.
Excerpted from Wikipedia’s “alisporivir” article, available under the CC BY-SA 4.0 licence.