Chromogranin A
Sign in to saveAlso known as chromofungin, catestatin, CgA, SP-I, parathyroid secretory protein 1, chromogranin-A, CHGA, betagranin (N-terminal fragment of chromogranin A)
Chromogranin-A (CgA) or parathyroid secretory protein 1 is encoded in the human by the 'gene CHGA'''''. Cga is a member of the granin family of neuroendocrine secretory proteins. As such, it is located in secretory vesicles of neurons and endocrine cells such as islet beta cell secretory granules in the pancreas.
Research
7,038 papers- Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation.Annals of the New York Academy of Sciences · 2019
- Chromogranin A.Clinical and investigative medicine. Medecine clinique et experimentale · 1995
- Chromogranin A.The New England journal of medicine · 1984
- [Chromogranin A and neuroendocrine tumors].Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion · 2013
- Chromogranin A and derived peptides in health and disease.Journal of molecular neuroscience : MN · 2012
via PubMed
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Encyclopedic overview
7 sectionsContents
- Tissue distribution
- Function
- Clinical significance
- Variants
- References
- Further reading
- External links
Chromogranin-A (CgA) or parathyroid secretory protein 1 is encoded in the human by the 'gene CHGA. Cga is a member of the granin family of neuroendocrine secretory proteins. As such, it is located in secretory vesicles of neurons and endocrine cells such as islet beta cell secretory granules in the pancreas.
== Tissue distribution == Examples of cells producing chromogranin-A (CgA) are chromaffin cells of the adrenal medulla, paraganglia, enterochromaffin-like cells and beta cells of the pancreas. It is present in islet beta cell secretory granules. chromogranin-A (CgA)+ Pulmonary neuroendocrine cells account for 0.41% of all epithelial cells in the conducting airway, but are absent from the alveoli.
Excerpted from Wikipedia’s “Chromogranin A” article, available under the CC BY-SA 4.0 licence.