Structure via PubChem · Public domain (PubChem)
anisindione
Sign in to saveAlso known as 2-(P-Methoxyphenyl)-1,3-indandione, 2-para-anisyl-1,3-indandione, 2-p-anisyl-1,3-indandione, 2-(p-methoxyphenyl)indane-1,3-dione, 2-(p-methoxyphenyl)-1,3-indandione, 2-(4-methoxyphenyl)indan-1,3-dione, 2-(4-methoxyphenyl)-1H-indene-1,3(2H)-dione, anisin indandione
Anisindione (brand name Miradon) is a synthetic anticoagulant and an 1,3-indandione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.
Chemical data
- Formula
- C16H12O3
- Molecular weight
- 252.26 g/mol
- IUPAC name
- 2-(4-methoxyphenyl)indene-1,3-dione
- SMILES
- COC1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
- InChIKey
- XRCFXMGQEVUZFC-UHFFFAOYSA-N
- XLogP
- 2.9
- Polar surface area
- 43.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1957
- Admin. routes
- oral
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 252.078644
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₆H₁₂O₃
- medical condition treated
- pulmonary embolism
- canonical SMILES
- COC1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
- World Health Organisation international non-proprietary name
- anisindione
- physically interacts with
- Gamma-glutamyl carboxylase
- Commons category
- Anisindione
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Anisindione (brand name Miradon) is a synthetic anticoagulant and an 1,3-indandione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.
== References ==
Excerpted from Wikipedia’s “anisindione” article, available under the CC BY-SA 4.0 licence.