DL-ofloxacin

Also known as HOE-280, DL-8280, OFLX, 8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid, Floxin, (+/-)-9-fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, (+/-)-ofloxacin

Ofloxacin is a quinolone antibiotic useful for the treatment of a number of bacterial infections. When taken by mouth or injection into a vein, these include pneumonia, cellulitis, urinary tract infections, prostatitis, plague, and certain types of infectious diarrhea. Other uses, along with other medications, include treating multidrug resistant tuberculosis. An eye drop may be used for a superficial bacterial infection of the eye and an ear drop may be used for otitis media when a hole in the ear drum is present.

Key facts

Drug.Watchedfields: changed
Drug.verifiedrevid: 462264606
Drug.image: Ofloxacin.svg
Drug.image_class: skin-invert-image
Drug.width: 240
Drug.chirality: Racemic mixture
Drug.image2: Ofloxacin zwitterion ball from xtal.png
Drug.image_class2: bg-transparent
Drug.tradename: Floxin, Ocuflox, others
Drug.MedlinePlus: a691005
Drug.DailyMedID: Ofloxacin
Drug.routes_of_administration: By mouth, intravenous therapy, topical (eye drops and ear drops)

Article

14 sections

Contents

Medical uses
Susceptible bacteria
Adverse effects
Contraindications
Pregnancy
Children
Overdose
Pharmacokinetics
Mode of action
History
Society and culture
Available forms
Antibiotic use and bacterial resistance
References

When taken by mouth, common side effects include vomiting, diarrhea, headache, and rash. Other serious side effect include tendon rupture, numbness due to nerve damage, seizures, and psychosis. Use in pregnancy is typically not recommended. Ofloxacin is in the fluoroquinolone family of medications. It works by interfering with the bacterium's DNA.