Apelin
Sign in to saveAlso known as APJ endogenous ligand, AGTRL1 ligand, APLN
Apelin (also known as APLN) is a peptide that in humans is encoded by the APLN gene. Apelin is one of two endogenous ligands for the G-protein-coupled APJ receptor that is expressed at the surface of some cell types. It is widely expressed in various organs such as the heart, lung, kidney, liver, adipose tissue, gastrointestinal tract, brain, adrenal glands, endothelium, and human plasma.
Protein · UniProt
Apelin
- Gene
- APLN
- Organism
- Homo sapiens (Human)
- Length
- 77 aa
- Molecular mass
- 8,569 Da
- Evidence
- 1: Evidence at protein level
Peptide hormone that functions as endogenous ligand for the G protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis (PubMed:10525157, PubMed:22810587, PubMed:35817871, PubMed:38428423). Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR (PubMed:22810587, PubMed:38428423). Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs (PubMed:22810587, PubMed:35817871, PubMed:38428423). On the other hand, APLNR activation induces beta-arrestin…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 2 more facts
- biological process
- gastrulation
- found in taxon
- Homo sapiens
via Wikidata · CC0
~8 min read
Encyclopedic overview
14 sectionsContents
- Discovery
- Biosynthesis
- Physiological functions
- Vascular
- Cardiac
- Exercise
- Brain
- Adipose tissue
- Digestive
- Bone
- Muscle aging
- References
- Further reading
- External links
Apelin (also known as APLN) is a peptide that in humans is encoded by the APLN gene. Apelin is one of two endogenous ligands for the G-protein-coupled APJ receptor that is expressed at the surface of some cell types. It is widely expressed in various organs such as the heart, lung, kidney, liver, adipose tissue, gastrointestinal tract, brain, adrenal glands, endothelium, and human plasma.
== Discovery ==
Excerpted from Wikipedia’s “Apelin” article, available under the CC BY-SA 4.0 licence.