APLNR
Sign in to saveAlso known as AGTRL1, APJ, APJR, HG11, apelin receptor
protein-coding gene in the species Homo sapiens
Gene data
APLNR- Name
- apelin receptor
- Type
- protein-coding
- Position
- 57,233,577–57,237,250 (−)
- Aliases
- AGTRL1, APJ, APJR, HG11
- Ensembl
- ENSG00000134817
- RefSeq RNA
- NM_005161.6, NR_027991.2
- RefSeq protein
- NP_005152.1
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
apelin receptor
- Symbol
- APLNR
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:57,233,577-57,237,250
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 3784
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/187
- genomic end
- 57237250
- genomic start
- 57001051
- chromosome
- human chromosome 11
- cytogenetic location
- 11q12.1
- expressed in
- spleen
Sources (4)
via Wikidata · CC0