adipokine
Sign in to saveAlso known as adipocytokine, adipokines
The adipokines, or adipocytokines (Greek ', fat; ', cell; and '''', movement) are cytokines (cell signaling proteins) secreted by adipose tissue. Some contribute to an obesity-related low-grade state of inflammation or to the development of metabolic syndrome, a constellation of diseases including, but not limited to, type 2 diabetes, cardiovascular disease and atherosclerosis. The first adipokine to be discovered was leptin in 1994. Since that time, hundreds of adipokines have been discovered.
Research
54,677 papers- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment.Journal of the American College of Cardiology · 2025
- Adipokine and fat body in flies: Connecting organs.Molecular and cellular endocrinology · 2021
- The Adipokine Network in Rheumatic Joint Diseases.International journal of molecular sciences · 2019
- Adipokine Dysregulation and Insulin Resistance with Atherosclerotic Vascular Disease: Metabolic Syndrome or Independent Sequelae?Journal of cardiovascular translational research · 2019
- Gut microbiota and regulation of myokine-adipokine function.Current opinion in pharmacology · 2020
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Encyclopedic overview
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The adipokines, or adipocytokines (Greek ', fat; ', cell; and '''', movement) are cytokines (cell signaling proteins) secreted by adipose tissue. Some contribute to an obesity-related low-grade state of inflammation or to the development of metabolic syndrome, a constellation of diseases including, but not limited to, type 2 diabetes, cardiovascular disease and atherosclerosis. The first adipokine to be discovered was leptin in 1994. Since that time, hundreds of adipokines have been discovered.
Members include: Leptin Adiponectin Apelin chemerin interleukin-6 (IL-6) monocyte chemotactic protein-1 (MCP-1) plasminogen activator inhibitor-1 (PAI-1) retinol binding protein 4 (RBP4) tumor necrosis factor visfatin omentin vaspin (SERPINA12) progranulin CTRP-4
Excerpted from Wikipedia’s “adipokine” article, available under the CC BY-SA 4.0 licence.