ARHGEF11

Also known as GTRAP48, PDZ-RHOGEF, Rho guanine nucleotide exchange factor 11

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF.

Gene data

ARHGEF11

Name: Rho guanine nucleotide exchange factor 11
Type: protein-coding
Position: 156,934,840–157,046,903 (−)
Aliases: GTRAP48, PDZ-RHOGEF
Ensembl: ENSG00000132694
RefSeq RNA: NM_001377418.1, NM_001377419.1, NM_014784.4, NM_198236.3, XM_005245629.6
RefSeq protein: NP_001364347.1, NP_001364348.1, NP_055599.1, NP_937879.1, XP_005245686.1

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

Pathways

Vascular smooth muscle contraction - Homo sapiens (human)Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)Pathogenic Escherichia coli infection - Homo sapiens (human)Human cytomegalovirus infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Developmental Biology Signal Transduction NRAGE signals death through JNK p75 NTR receptor-mediated signalling Signaling by Rho GTPases

via MyGene.info

Gene · Ensembl

Rho guanine nucleotide exchange factor 11

Symbol: ARHGEF11
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:156,934,840-157,046,903
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

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Encyclopedic overview

6 sections

Contents

Function
Interactions
See also
References
Further reading
External links

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF.

== Function == Rho guanine nucleotide exchange factor 11 is guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But when acted on by Rho GEF proteins such as RhoGEF1, this GDP is released and replaced by GTP, leading to the active state of Rho. In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate cellular functions. In particular, active Rho is a major regulator of the cell actin cytoskeleton.

Excerpted from Wikipedia’s “ARHGEF11” article, available under the CC BY-SA 4.0 licence.