RHOA
Sign in to saveAlso known as ARH12, ARHA, RHO12, RHOH12, ras homolog family member A, EDFAOB
protein-coding gene in the species Homo sapiens
Gene data
RHOA- Name
- ras homolog family member A
- Type
- protein-coding
- Position
- 49,359,136–49,412,998 (−)
- Aliases
- ARH12, ARHA, EDFAOB, RHO12, RHOH12
- Ensembl
- ENSG00000067560
- RefSeq RNA
- NM_001313941.2, NM_001313943.2, NM_001313944.2, NM_001313945.2, NM_001313946.2
- RefSeq protein
- NP_001300870.1, NP_001300872.1, NP_001300873.1, NP_001300874.1, NP_001300875.1
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
Molecular function
Pathways
Ras signaling pathway - Homo sapiens (human)Rap1 signaling pathway - Homo sapiens (human)cGMP-PKG signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)Sphingolipid signaling pathway - Homo sapiens (human)Phospholipase D signaling pathway - Homo sapiens (human)Endocytosis - Homo sapiens (human)mTOR signaling pathway - Homo sapiens (human)Vascular smooth muscle contraction - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
ras homolog family member A
- Symbol
- RHOA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:49,359,136-49,412,998
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein RHOA PDB 1a2b.png
Show 6 more facts
- HomoloGene ID
- 68986
- genomic end
- 49450431
- exact match
- identifiers.org/ncbigene/387
- genomic start
- 49359139
- cytogenetic location
- 3p21.31
- Commons category
- RhoA GTP-binding protein
via Wikidata · CC0
Connections
Q180686
Entity
Ensembl genome database project
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translation elongation factor
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protein
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International Standard Book Number
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enzyme
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Wikidata
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gene
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chromosome
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Wayback Machine
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digital object identifier
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cell division
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bibcode
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human genome
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Q229883
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base pair
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actin
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Medical Subject Headings
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locus
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gene expression
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