asialoglycoprotein
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If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.
Research
3,341 papers- The hepatic asialoglycoprotein receptor.CRC critical reviews in biochemistry · 1984
- Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.Nature · 2022
- The asialoglycoprotein receptor: a model for endocytic transport receptors.Biochemistry · 1990
- The asialoglycoprotein receptor: relationships between structure, function, and expression.Physiological reviews · 1995
- Trafficking of asialoglycoproteins and the asialoglycoprotein receptor.Targeted diagnosis and therapy · 1991
via PubMed
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Encyclopedic overview
2 sectionsContents
- External links
- References
If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.
In rats, the exposure of subterminal galactose or GalNAc residues may assist in receptor-mediated endocytosis of asialoglycoproteins by asialoglycoprotein receptors on Kuppfer cells. The human ortholog of this gene is non-functional, but hepatocyte asialoglycoprotein receptors are functional in both humans and rats.
Excerpted from Wikipedia’s “asialoglycoprotein” article, available under the CC BY-SA 4.0 licence.