Mucin 16, cell surface associated
Sign in to saveAlso known as ovarian carcinoma antigen CA125, CA-125, mucin-16, ovarian cancer-related tumor marker CA125, mucin-16 short isoform, mucin-16 long isoform, MUC16, CA125 ovarian cancer antigen
Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the MUC16 gene. MUC-16 is a member of the mucin family glycoproteins. MUC-16 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, most notably ovarian cancer, or other conditions that are benign.
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Vinony's link graph records 152 inbound references to Mucin 16, cell surface associated, and connects out to mucin, amino acid and PubMed.
It sits within the topics Genes on human chromosome 19, Proteins and Tumor markers.
Vinony links it to 17 Wikipedia language editions.
Protein · UniProt
Mucin-16
- Gene
- MUC16
- Organism
- Homo sapiens (Human)
- Length
- 14,507 aa
- Molecular mass
- 1,519,175 Da
- Evidence
- 1: Evidence at protein level
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces
Swiss-Prot (reviewed) · via UniProt
Research
112 papers- Biomarkers of ocular allergy and dry eye disease.Romanian journal of ophthalmology · 2023
- Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.Human pathology · 2012
- Tumour extracellular vesicle surface Protein-mRNA integration assay for early detection of epithelial ovarian cancer.EBioMedicine · 2025
- Quantification of MUCIN 1, cell surface associated and MUCIN16, cell surface associated proteins in tears and conjunctival epithelial cells collected from postmenopausal women.Molecular vision · 2013
- Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue.Investigative ophthalmology & visual science · 2019
via PubMed
Clinical Trials
1 registered- COMPLETEDMucin Levels in Dry Eye and Normal PopulationsORA, Inc. · NCT05911555
Wikidata facts
- Instance of
- biomarker
- Image
- Interaction of MUC16-CA125 and mesothelin.tiff
Show 3 more facts
- molecular function
- protein binding
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~6 min read
Encyclopedic overview
10 sectionsContents
- Structure
- Function
- Role in cancer
- As a biomarker
- Metastatic invasion
- Induced motility
- Chemotherapy resistance
- Discovery
- References
- External links
Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the MUC16 gene. MUC-16 is a member of the mucin family glycoproteins. MUC-16 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, most notably ovarian cancer, or other conditions that are benign.
== Structure ==
Excerpted from Wikipedia’s “Mucin 16, cell surface associated” article, available under the CC BY-SA 4.0 licence.