Mucin 16, cell surface associated
Sign in to saveAlso known as ovarian carcinoma antigen CA125, CA-125, mucin-16, ovarian cancer-related tumor marker CA125, mucin-16 short isoform, mucin-16 long isoform, MUC16, CA125 ovarian cancer antigen
Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the MUC16 gene. MUC-16 is a member of the mucin family glycoproteins. MUC-16 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, most notably ovarian cancer, or other conditions that are benign.
Protein · UniProt
Mucin-16
- Gene
- MUC16
- Organism
- Homo sapiens (Human)
- Length
- 14,507 aa
- Molecular mass
- 1,519,175 Da
- Evidence
- 1: Evidence at protein level
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces
Swiss-Prot (reviewed) · via UniProt
Research
112 papers- Biomarkers of ocular allergy and dry eye disease.Romanian journal of ophthalmology · 2023
- Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.Human pathology · 2012
- Tumour extracellular vesicle surface Protein-mRNA integration assay for early detection of epithelial ovarian cancer.EBioMedicine · 2025
- Quantification of MUCIN 1, cell surface associated and MUCIN16, cell surface associated proteins in tears and conjunctival epithelial cells collected from postmenopausal women.Molecular vision · 2013
- Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue.Investigative ophthalmology & visual science · 2019
via PubMed
Clinical Trials
1 registered- COMPLETEDMucin Levels in Dry Eye and Normal PopulationsORA, Inc. · NCT05911555
Wikidata facts
- Instance of
- biomarker
- Image
- Interaction of MUC16-CA125 and mesothelin.tiff
Show 3 more facts
- molecular function
- protein binding
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~6 min read
Encyclopedic overview
10 sectionsContents
- Structure
- Function
- Role in cancer
- As a biomarker
- Metastatic invasion
- Induced motility
- Chemotherapy resistance
- Discovery
- References
- External links
Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the MUC16 gene. MUC-16 is a member of the mucin family glycoproteins. MUC-16 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, most notably ovarian cancer, or other conditions that are benign.
== Structure ==
Excerpted from Wikipedia’s “Mucin 16, cell surface associated” article, available under the CC BY-SA 4.0 licence.