ATF6

Also known as ATF6A, ACHM7, activating transcription factor 6

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein response.

Gene data

ATF6

Name: activating transcription factor 6
Type: protein-coding
Position: 161,766,261–161,977,574 (+)
Aliases: ACHM7, ATF6A, ATP6alpha
Ensembl: ENSG00000118217
RefSeq RNA: NM_001410890.1, NM_001437597.1, NM_007348.4, XM_011509309.1, XM_011509310.3
RefSeq protein: NP_001397819.1, NP_001424526.1, NP_031374.2, XP_011507611.1, XP_011507612.1

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011].

Gene Ontology

Biological process

eye development regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II protein folding signal transduction visual perception

Molecular function

transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity

Cellular component

Golgi membrane Golgi membrane chromatin fibrillar center nucleus nucleus nucleus nucleus

Pathways

Protein processing in endoplasmic reticulum - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Amyotrophic lateral sclerosis - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)Lipid and atherosclerosis - Homo sapiens (human)Cytokine Signaling in Immune system Immune System Cellular responses to stress Cellular responses to stress

via MyGene.info

Research

3,462 papers

ATF6 as a Nodal Regulator of Proteostasis in the Heart.Frontiers in physiology · 2020
ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.Cancer research communications · 2024
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.Cell · 2001
GRINA alleviates hepatic ischemia‒reperfusion injury-induced apoptosis and ER-phagy by enhancing HRD1-mediated ATF6 ubiquitination.Journal of hepatology · 2025
ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis.Theranostics · 2020

via PubMed

Wikidata facts

Show 5 more facts

HomoloGene ID: 32015
exact match: identifiers.org/ncbigene/22926
genomic end: 161977574
genomic start: 161766298
cytogenetic location: 1q23.3

Sources (6)

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Article

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Contents

Function
Interactions
See also
References
Further reading
External links

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein response.

== Function ==