RBPJ

Also known as AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH

Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.

Gene data

RBPJ

Name: recombination signal binding protein for immunoglobulin kappa J region
Type: protein-coding
Position: 26,163,455–26,435,131 (+)
Aliases: AOS3, CBF-1, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBP-J kappa, RBP-JK, RBPJK
Ensembl: ENSG00000168214
RefSeq RNA: NM_001363577.2, NM_001374400.1, NM_001374401.1, NM_001374402.1, NM_001374403.1
RefSeq protein: NP_001350506.1, NP_001361329.1, NP_001361330.1, NP_001361331.1, NP_001361332.1

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II angiogenesis epithelial to mesenchymal transition blood vessel remodeling blood vessel remodeling outflow tract morphogenesis

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding

Cellular component

chromatin MAML1-RBP-Jkappa- ICN1 complex MAML1-RBP-Jkappa- ICN1 complex nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Notch signaling pathway - Homo sapiens (human)Th1 and Th2 cell differentiation - Homo sapiens (human)Spinocerebellar ataxia - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Developmental Biology Signaling by NOTCH Signaling by NOTCH Signal Transduction

via MyGene.info

Gene · Ensembl

recombination signal binding protein for immunoglobulin kappa J region

Symbol: RBPJ
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:26,163,455-26,435,131
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Research

1,124 papers

Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response.Advances in experimental medicine and biology · 2021
TRIM59/RBPJ positive feedback circuit confers gemcitabine resistance in pancreatic cancer by activating the Notch signaling pathway.Cell death & disease · 2024
Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease.Immunity · 2024
Short-term starvation inhibits CD36 N-glycosylation and downregulates USP7 UFMylation to alleviate RBPJ-maintained T cell exhaustion in liver cancer.Theranostics · 2025
Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice.Hepatology communications · 2025

via PubMed

~1 min read

Encyclopedic overview

4 sections

Contents

Interactions
References
Further reading
External links

Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.

RBPJ also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.

Excerpted from Wikipedia’s “RBPJ” article, available under the CC BY-SA 4.0 licence.