バゼドキシフェン

Also known as Conbriza®, TSE-424, Viviant®, WAY-140424, bazedoxifene/conjugated estrogens, Bazedoxifene

Bazedoxifene, used as bazedoxifene acetate, is a medication for bone problems and possibly (pending more study) for cancer. It is a third-generation selective estrogen receptor modulator (SERM). Since late 2013 it has had U.S. FDA approval for bazedoxifene as part of the combination drug Duavee in the prevention (not treatment) of postmenopausal osteoporosis. It is also being studied for possible treatment of breast cancer and pancreatic cancer.

Chemical data

Formula: C30H34N2O3
Molecular weight: 470.6 g/mol
IUPAC name: 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol
SMILES: CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=C(C=C5)O
InChIKey: UCJGJABZCDBEDK-UHFFFAOYSA-N
XLogP: 6.1
Polar surface area: 57.9 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2009
Admin. routes: oral
Indications: postmenopausal osteoporosis, osteoporosis, breast ductal carcinoma in situ, breast cancer

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 470.257
Has use: medication

Show 7 more facts

chemical formula: C₃₀H₃₄N₂O₃
canonical SMILES: CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=C(C=C5)O
defined daily dose: 20
subject has role: selective estrogen-receptor modulators
significant drug interaction: phenytoin
Commons category: Bazedoxifene
legal status (medicine): boxed warning

Sources (4)

via Wikidata · CC0

Article · 日本語

バゼドキシフェン(bazedoxifene)は骨粗鬆症治療薬のひとつ。バゼドキシフェン酢酸塩として用いられる。(がんの治療の可能性については多くの研究を保留中である）この薬剤は第三世代の選択的エストロゲン受容体モジュレーター（SERM）である。 2013年後半以来、閉経後骨粗鬆症の予防（治療ではないにおける合剤 Duaveeの一部として、バゼドキシフェンに対する米国FDAの承認を受けている。乳がんと膵臓がんの治療の可能性についても研究されている。

Abstract from DBpedia / Wikipedia · CC BY-SA

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