BCL2L2
Sign in to saveAlso known as BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 2
Bcl-2-like protein 2 is a 193-amino acid protein that in humans is encoded by the BCL2L2 gene on chromosome 14 (band q11.2-q12). It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w.
Gene data
BCL2L2- Name
- BCL2 like 2
- Type
- protein-coding
- Aliases
- BCL-W, BCL2-L-2, BCLW, PPP1R51
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010].
via MyGene.info
Wikidata facts
- Image
- Protein BCL2L2 PDB 1mk3.png
Show 5 more facts
- HomoloGene ID
- 2989
- exact match
- identifiers.org/ncbigene/599
- genomic end
- 23794578
- genomic start
- 23776044
- cytogenetic location
- 14q11.2
Sources (3)
via Wikidata · CC0
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Article
6 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
- External links
Bcl-2-like protein 2 is a 193-amino acid protein that in humans is encoded by the BCL2L2 gene on chromosome 14 (band q11.2-q12). It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w.
== Function == This gene encodes a pro-survival (anti-apoptotic) member of the Bcl-2 protein family, and is most similar to Bcl-xL. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.