BECN1
Sign in to saveAlso known as ATG6, VPS30, beclin1, beclin 1
Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.
Gene data
BECN1- Name
- beclin 1
- Type
- protein-coding
- Position
- 42,809,870–42,833,350 (−)
- Aliases
- ATG6, VPS30, beclin1
- Ensembl
- ENSG00000126581
- RefSeq RNA
- NM_001313998.2, NM_001313999.1, NM_001314000.2, NM_003766.5, XM_005257759.4
- RefSeq protein
- NP_001300927.1, NP_001300928.1, NP_001300929.1, NP_003757.1, XP_005257816.1
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein BECN1 PDB 2p1l.png
Show 5 more facts
- HomoloGene ID
- 2794
- exact match
- identifiers.org/ncbigene/8678
- genomic start
- 40962152
- genomic end
- 40985367
- cytogenetic location
- 17q21.31
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Article
7 sectionsContents
- Role in disease
- Interactions
- Modulators
- Trehalose
- References
- Further reading
- External links
Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.
== Role in disease ==