PPP1CA

Name

protein phosphatase 1 catalytic subunit alpha

Type

protein-coding

Position

67,398,176–67,421,183 (−)

Aliases

PP-1A, PP1A, PP1alpha, PPP1A

Ensembl

ENSG00000172531

RefSeq RNA

NM_001008709.2, NM_002708.4, NM_206873.2

RefSeq protein

NP_001008709.1, NP_002699.1, NP_996756.1

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020].

via MyGene.info

Gene · Ensembl

protein phosphatase 1 catalytic subunit alpha

Symbol

PPP1CA

Biotype

Protein coding

Organism

Homo sapiens

Location

11:67,398,176-67,421,183

Strand

Reverse (−)

Assembly

GRCh38