Brain derived neurotrophic factor

Protein · UniProt

Neurotrophic factor BDNF precursor form

Gene

BDNF

Organism

Homo sapiens (Human)

Length

247 aa

Molecular mass

27,818 Da

Evidence

1: Evidence at protein level

Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term …

• EARLY_PHASE1RECRUITING
  Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood DisturbanceAuburn University · NCT06531863
• PHASE4ACTIVE_NOT_RECRUITING
  Effect of L-carnitine Supplementation on Phenylalanine and Brain-derived Neurotrophic Factor Levels in Infants and Children With PhenylketonuriaMansoura University · NCT06901323
• NACOMPLETED
  Multi-faceted Evaluations Following Weight Reduction in Subjects With Metabolic SyndromeTaichung Veterans General Hospital · NCT01065753
• NARECRUITING
  Exergaming Training Among Hypertensive PatientsRiphah International University · NCT06777927
• NAUNKNOWN
  The Potential Role of SI00B and Brain Derived Neurotrophic Factor in Predicting Outcome From Using Pulsed Radiofrequency in Treatment of Patients With Lumbar Disc ProlapsedBeni-Suef University · NCT05193461
• NACOMPLETED
  Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major DepressionTirat Carmel Mental Health Center · NCT00944996

via ClinicalTrials.gov