motesanib
Sign in to saveAlso known as AMG 706, AMG-706, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-((4-pyridinylmethyl)amino)-3-pyridinecarboxamide
Motesanib (AMG 706) is an experimental drug candidate originally developed by Amgen but later investigated by the Takeda Pharmaceutical Company. It is an orally administered small molecule belonging to angiokinase inhibitor class which acts as an antagonist of VEGF receptors, platelet-derived growth factor receptors, and stem cell factor receptors. It is used as the phosphate salt motesanib diphosphate. After clinical trials in thyroid cancer, non-small cell lung cancer, gastrointestinal stromal cancer, colorectal cancer, and breast cancer, the drug was not found to show sufficient efficacy fo
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 373.19
- Has use
- medication
Show 3 more facts
- subject has role
- enzyme inhibitor
- chemical formula
- C₂₂H₂₃N₅O
- canonical SMILES
- CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
3 sectionsContents
- Clinical trials
- References
- External links
{{chembox | ImageFile = Motesanib.svg | ImageClass = skin-invert-image | ImageSize = 200px | PIN = N-(3,3-Dimethyl-2,3-dihydro-1H-indol-6-yl)-2-{[(pyridin-4-yl)methyl]amino}pyridine-3-carboxamide | OtherNames = AMG 706 |Section1= |Section2= |Section3= }}
Motesanib (AMG 706) is an experimental drug candidate originally developed by Amgen but later investigated by the Takeda Pharmaceutical Company. It is an orally administered small molecule belonging to angiokinase inhibitor class which acts as an antagonist of VEGF receptors, platelet-derived growth factor receptors, and stem cell factor receptors. It is used as the phosphate salt motesanib diphosphate. After clinical trials in thyroid cancer, non-small cell lung cancer, gastrointestinal stromal cancer, colorectal cancer, and breast cancer, the drug was not found to show sufficient efficacy for further development, and development was abandoned by Takeda.
Excerpted from Wikipedia’s “motesanib” article, available under the CC BY-SA 4.0 licence.