brincidofovir
Sign in to saveBrincidofovir, sold under the brand name Tembexa, is an antiviral drug used to treat smallpox. Brincidofovir is a prodrug of cidofovir. Conjugated to a lipid, the compound is designed to release cidofovir intracellularly, allowing for higher intracellular and lower plasma concentrations of cidofovir, effectively increasing its activity against dsDNA viruses, as well as oral bioavailability.
Key facts
- Drug.image
- Brincidofovir structure.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Tembexa
- Drug.DailyMedID
- Brincidofovir
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- J05
- Drug.ATC_suffix
- AB17
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.index2_label
- Sodium salt
- Drug.CAS_number
- 444805-28-1
- Drug.CAS_number2
- 496765-79-8
- Drug.PubChem
- 483477
- Drug.DrugBank
- DB12151
- Drug.DrugBank2
- DBSALT002145
- Drug.ChemSpiderID
- 424003
- Drug.ChemSpiderID2
- 21259112
- Drug.UNII
- 6794O900AX
via Wikipedia infobox
~10 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- Mechanism of action
- Pharmacokinetics
- History
- Expanded access ethical considerations
- Research
- Adenovirus and cytomegalovirus
- Ebola
- Animals
- References
- Further reading
- External links
{{Infobox drug | image = Brincidofovir structure.svg | image_class = skin-invert-image | alt = | caption =
| pronounce = | tradename = Tembexa | Drugs.com = | MedlinePlus = | DailyMedID = Brincidofovir | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = | ATC_prefix = J05 | ATC_suffix = AB17 | ATC_supplemental =
Excerpted from Wikipedia’s “brincidofovir” article, available under the CC BY-SA 4.0 licence.