BTNL2

Name

butyrophilin like 2

Type

protein-coding

Position

32,391,481–32,407,181 (−)

Aliases

BTL-II, BTN7, HSBLMHC1, SS2

Ensembl

ENSG00000229741

RefSeq RNA

NM_001304561.2, NM_019602.1, XM_054330320.1, XM_054330617.1, XM_054330837.1

RefSeq protein

NP_001291490.1, XP_054186295.1, XP_054186592.1, XP_054186812.1, XP_054187343.1

This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017].

via MyGene.info

Gene · Ensembl

butyrophilin like 2

Symbol

BTNL2

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HSCHR6_MHC_MCF_CTG1:3,735,713-3,748,885

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

via Wikidata · CC0