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sarcoidosis

File:Chest_X-ray_of_sarcoidosis_nodules.png · Wikimedia Commons · See Wikimedia Commons

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sarcoidosis

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Also known as Boeck sarcoid, benign lymphogranulomatosis, Besnier-Boeck-Schaumann disease, lymphogranulomatosis

Sarcoidosis, also known as Besnier–Boeck–Schaumann disease, is a non-infectious granulomatous disease involving abnormal collections of inflammatory cells that form lumps known as granulomata. The disease usually begins in the lungs, skin, or lymph nodes. Less commonly affected are the eyes, liver, heart, and brain, though any organ can be affected. The signs and symptoms depend on the organ involved. Often, no symptoms or only mild symptoms are seen. When it affects the lungs, wheezing, coughing, shortness of breath, or chest pain may occur. Some may have Löfgren syndrome, with fever, enlarge

AI overview

Sarcoidosis is a disease in which inflammatory cells abnormally clump together to form lumps called granulomata, most commonly affecting the lungs, skin, or lymph nodes, though it can involve any organ. The condition is serious because symptoms vary widely depending on which organs are affected—ranging from none at all to breathing problems, chest pain, and other complications—making diagnosis and treatment challenging.

AI-generated from the Wikipedia summary — may contain errors.

Key facts

Medical condition.name
Sarcoidosis
Medical condition.synonyms
Sarcoïdosis, sarcoid, Besnier–Boeck–Schaumann disease
Medical condition.image
Chest X-ray of sarcoidosis nodules.png
Medical condition.caption
Chest X-ray showing the typical nodularity of sarcoidosis, predominantly in the hila of the lungs.
Medical condition.field
Rheumatology, immunology
Medical condition.onset
20–50 years old More common in women
Medical condition.duration
Few years to long term
Medical condition.causes
Unknown
Medical condition.risks
Family history
Medical condition.diagnosis
Based on symptoms and tissue biopsy
Medical condition.differential
Tuberculosis, lymphoma, infectious mononucleosis, pulmonary eosinophilia
Medical condition.treatment
Ibuprofen, prednisone, methotrexate
Medical condition.prognosis
Mortality 1–7%
Medical condition.frequency
1.9 million with interstitial lung disease (2015)
Medical condition.deaths
122,000 with interstitial lung disease (2015)

via Wikipedia infobox

Research

37,709 papers

via PubMed

Wikidata facts

Subclass of
disease
Named after
Ernest Besnier
Image
Chest X-ray of sarcoidosis nodules.png
Show 11 more facts
Commons category
Sarcoidosis
NCI Thesaurus ID
C34995
health specialty
ophthalmology
genetic association
BTNL2
exact match
www.orpha.net/ORDO/Orphanet_797
ICD-9-CM
135
symptoms and signs
dyspnea
possible treatment
methotrexate
external data available at URL
www.nanbyou.or.jp/entry/110
prevalence
0.0016
on focus list of Wikimedia project
WikiProject Medicine
Sources (11)

via Wikidata · CC0

~38 min read

Encyclopedic overview

31 sections
Contents
  • Signs and symptoms
  • Respiratory tract
  • Skin
  • Bone, joints, and muscles
  • Heart
  • Eye
  • Nervous system
  • Endocrine and exocrine
  • Gastrointestinal and genitourinary
  • Blood
  • Cause
  • Genetics
  • Infectious agents
  • Autoimmune
  • Pathophysiology
  • Histopathology
  • Diagnosis
  • Classification
  • Treatment
  • Antimetabolites
  • Immunosuppressants
  • Specific organ treatments
  • Symptoms
  • Prognosis
  • Epidemiology
  • History
  • Etymology
  • Society and culture
  • Pregnancy
  • References
  • External links

Sarcoidosis, also known as Besnier–Boeck–Schaumann disease, is a non-infectious granulomatous disease involving abnormal collections of inflammatory cells that form lumps known as granulomata. The disease usually begins in the lungs, skin, or lymph nodes. Less commonly affected are the eyes, liver, heart, and brain, though any organ can be affected. The signs and symptoms depend on the organ involved. Often, no symptoms or only mild symptoms are seen. When it affects the lungs, wheezing, coughing, shortness of breath, or chest pain may occur. Some may have Löfgren syndrome, with fever, enlarged hilar lymph nodes, arthritis, and a rash known as erythema nodosum.

The cause of sarcoidosis is unknown. Some believe it may be due to an immune reaction to a trigger such as an infection or chemicals in those who are genetically predisposed. Those with affected family members are at greater risk. Diagnosis is partly based on signs and symptoms, which may be supported by biopsy. Findings that make it likely include large lymph nodes at the root of the lung on both sides, high blood calcium with a normal parathyroid hormone level, or elevated levels of angiotensin-converting enzyme in the blood. The diagnosis should be made only after excluding other possible causes of similar symptoms such as tuberculosis.

Excerpted from Wikipedia’s “sarcoidosis” article, available under the CC BY-SA 4.0 licence.

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