C5+1

thumb|right|John Kerry (far left) with the Central Asian foreign ministers during the 70th Regular Session of the UN General Assembly in New York on September 26, 2015. The C5+1 is a diplomatic summit that has been held every year since 2015 between the foreign ministers of the five Central Asian countries of Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan, with the United States Secretary of State to discuss and work on common issues of concern to improve and strengthen the U.S. relationship with the five Central Asian states, but to also enhance the relations between the individual nations in Central Asia. The format is used to discuss regional issues such as the war in Afghanistan, the Syrian civil war, the war on terror, combating drug and human trafficking, economic issues regarding trade relations, job growth in the region, and combating environmental issues.

The C5+1 is viewed as an attempt by the United States to gain influence in the Central Asian states countering Russia where U.S.–Russian relations have worsened since 2014, and what the U.S. has perceived as being Russia's ambitions to restore the Soviet Union.