cadherin
Sign in to savethumb|350px|Principal interactions of structural proteins at cadherin-based adherens junction. Actin filaments are linked to α-actinin and to the membrane through vinculin. The head domain of vinculin is associated with E-cadherin via α-, β-, and γ-catenins. The tail domain of vinculin binds to membrane lipids and to actin filaments. Cadherins (named for "calcium-dependent adhesion") are cell adhesion molecules important in forming adherens junctions that let cells adhere to each other. Cadherins are a class of type-1 transmembrane proteins, and they depend on calcium (Ca2+) ions to function,
Key facts
- Protein family.Symbol
- Cadherin
- Protein family.image
- File:ECadherin repeating unit.png
- Protein family.caption
- Ribbon representation of a repeating unit in the extracellular E-cadherin ectodomain of the mouse ()
- Protein family.Pfam
- PF00028
- Protein family.InterPro
- IPR002126
- Protein family.SMART
- CA
- Protein family.Prosite
- PDOC00205
- Protein family.SCOP
- 1nci
- Protein family.Membranome superfamily
- 114
- Protein family.below
- See for other Cadherin families.
- Protein family.Name
- Cadherin domain (repeat)
via Wikipedia infobox
Research
53,713 papers- The cell-cell adhesion molecule E-cadherin.Cellular and molecular life sciences : CMLS · 2008
- VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity.Developmental cell · 2013
- Cadherin switching.Journal of cell science · 2008
- Aberrant N-cadherin expression in cancer.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2019
- Cadherin recognition and adhesion.Current opinion in cell biology · 2012
via PubMed
Article
16 sectionsContents
- Background
- Structure
- Function
- Development
- Tumour metastasis
- Correlation to cancer
- Correlation to endometrium and embryogenesis
- Types
- Classical
- Desmosomal
- Protocadherins
- Unconventional/ungrouped
- See also
- References
- Further reading
- External links
thumb|350px|Principal interactions of structural proteins at cadherin-based adherens junction. Actin filaments are linked to α-actinin and to the membrane through vinculin. The head domain of vinculin is associated with E-cadherin via α-, β-, and γ-catenins. The tail domain of vinculin binds to membrane lipids and to actin filaments. Cadherins (named for "calcium-dependent adhesion") are cell adhesion molecules important in forming adherens junctions that let cells adhere to each other. Cadherins are a class of type-1 transmembrane proteins, and they depend on calcium (Ca2+) ions to function, hence their name. Cell-cell adhesion is mediated by extracellular cadherin domains, whereas the intracellular cytoplasmic tail associates with numerous adaptors and signaling proteins, collectively referred to as the cadherin adhesome.
==Background==