VCAM1

Also known as CD106, INCAM-100, vascular cell adhesion molecule 1

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.

Gene data

VCAM1

Name: vascular cell adhesion molecule 1
Type: protein-coding
Position: 100,719,684–100,739,045 (+)
Aliases: CD106, INCAM-100
Ensembl: ENSG00000162692
RefSeq RNA: NM_001078.4, NM_001199834.2, NM_080682.3
RefSeq protein: NP_001069.1, NP_001186763.1, NP_542413.1

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010].

Pathways

NF-kappa B signaling pathway - Homo sapiens (human)Cell adhesion molecules - Homo sapiens (human)TNF signaling pathway - Homo sapiens (human)Leukocyte transendothelial migration - Homo sapiens (human)AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)African trypanosomiasis - Homo sapiens (human)Malaria - Homo sapiens (human)Lipid and atherosclerosis - Homo sapiens (human)Fluid shear stress and atherosclerosis - Homo sapiens (human)Cytokine Signaling in Immune system

via MyGene.info

Gene · Ensembl

vascular cell adhesion molecule 1

Symbol: VCAM1
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:100,719,684-100,739,045
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein VCAM1 PDB 1ij9.png

Show 6 more facts

HomoloGene ID: 838
exact match: identifiers.org/ncbigene/7412
genomic end: 101204601
genomic start: 101185298
cytogenetic location: 1p21.2
Commons category: Vascular cell adhesion molecule-1 (VCAM-1)

Sources (5)

via Wikidata · CC0

~2 min read

Article

6 sections

Contents

Structure
Function
Pharmacology
References
Further reading
External links

==Structure== VCAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines. It is alternatively spliced into two known RNA transcripts that encode different isoforms in humans. The gene product is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig superfamily.