PCDHA2

Name

protocadherin alpha 2

Type

protein-coding

Position

140,794,852–141,012,347 (+)

Aliases

PCDH-ALPHA2

Ensembl

ENSG00000291650

RefSeq RNA

NM_018905.3, NM_031495.2, NM_031496.2

RefSeq protein

NP_061728.1, NP_113683.1, NP_113684.1

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Image

Protein PCDHA2 PDB 1wuz.png

via Wikidata · CC0