CAST
Sign in to saveAlso known as BS-17, PLACK, calpastatin
Calpastatin is a protein that in humans is encoded by the CAST gene.
In the Vinony graph
Within Vinony's link graph, CAST is referenced by 7 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.
Vinony files it under EC 3.4, Genes on human chromosome 5 and Proteases.
Its subject is documented across 8 Wikipedia language editions.
Gene data
CAST- Name
- calpastatin
- Type
- protein-coding
- Aliases
- BS-17, MIR583HG, PLACK
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010].
via MyGene.info
Gene · Ensembl
calpastatin
- Symbol
- CAST
- Biotype
- LncRNA
- Organism
- Homo sapiens
- Location
- 5:95,962,001-96,631,085
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 7658
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/831
- genomic end
- 96115299
- genomic start
- 95860971
- chromosome
- human chromosome 5
- cytogenetic location
- 5q15
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Calpastatin is a protein that in humans is encoded by the CAST gene.
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1–4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length natures of only some have been determined.
Excerpted from Wikipedia’s “CAST” article, available under the CC BY-SA 4.0 licence.