calpain
Sign in to saveA calpain (; , ) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin.
Key facts
- Protein family.Symbol
- Calpain
- Protein family.Name
- Calpain
- Protein family.image
- PDB_1mdw_EBI.jpg
- Protein family.caption
- Crystal structure of the peptidase core of Calpain II.
- Protein family.Pfam
- PF00648
- Protein family.Pfam_clan
- CL0125
- Protein family.InterPro
- IPR001300
- Protein family.SMART
- CysPc
- Protein family.MEROPS
- C2
- Protein family.PROSITE
- PDOC50203
- Protein family.SCOP
- 1mdw
- Protein family.PDB
- A:55-354; B:55-354; A:55-354; B:55-354; A:55-353; B:45-344; A:45-344; L:45-344; L:45-344; A:42-337
- Enzyme.Name
- calpain-2
- Enzyme.EC_number
- 3.4.22.53
- Enzyme.CAS_number
- 702693-80-9
via Wikipedia infobox
Research
11,258 papers- Calpain and Cardiometabolic Diseases.International journal of molecular sciences · 2023
- Calpain.The international journal of biochemistry & cell biology · 2002
- Calpain-Mediated Alterations in Astrocytes Before and During Amyloid Chaos in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021
- Calpain-Mediated Mitochondrial Damage: An Emerging Mechanism Contributing to Cardiac Disease.Cells · 2021
- Calpain-1 and Calpain-2 in the Brain: What Have We Learned from 45 Years of Research?Cells · 2025
via PubMed
~10 min read
Article
11 sectionsContents
- Discovery
- Cleavage specificity
- Extended family
- Function
- Clinical significance
- Pathology
- Therapeutic inhibitors
- See also
- References
- Further reading
- External links
A calpain (; , ) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin.
== Discovery ==