CDKN3
Sign in to saveAlso known as CDI1, CIP2, KAP, KAP1, cyclin-dependent kinase inhibitor 3, cyclin dependent kinase inhibitor 3, CDLN3
gene umano
Gene data
CDKN3- Name
- cyclin dependent kinase inhibitor 3
- Type
- protein-coding
- Position
- 54,396,849–54,420,221 (+)
- Aliases
- CDI1, CIP2, KAP, KAP1
- Ensembl
- ENSG00000100526
- RefSeq RNA
- NM_001130851.2, NM_001330173.2, NM_005192.4
- RefSeq protein
- NP_001124323.1, NP_001317102.1, NP_005183.2
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Gene Ontology
Biological process
Molecular function
phosphoprotein phosphatase activityprotein serine/threonine phosphatase activityprotein serine/threonine phosphatase activityprotein serine/threonine phosphatase activityprotein tyrosine phosphatase activityprotein tyrosine phosphatase activityprotein tyrosine phosphatase activityprotein tyrosine phosphatase activity
via MyGene.info
Gene · Ensembl
cyclin dependent kinase inhibitor 3
- Symbol
- CDKN3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:54,396,849-54,420,221
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CDKN3 PDB 1fpz.png
Show 8 more facts
- HomoloGene ID
- 3805
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1033
- genomic end
- 54886936
- genomic start
- 54863567
- chromosome
- human chromosome 14
- cytogenetic location
- 14q22.2
- expressed in
- trabecular bone
Sources (4)
via Wikidata · CC0