PTPN11
Sign in to saveAlso known as BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.
In the Vinony graph
Within Vinony's link graph, PTPN11 is referenced by 200 other articles, and connects out to LEOPARD syndrome, Helicobacter pylori and PubMed.
Vinony files it under EC 3.1.3 and Genes on human chromosome 12.
Its subject is documented across 6 Wikipedia language editions.
Gene data
PTPN11- Name
- protein tyrosine phosphatase non-receptor type 11
- Type
- protein-coding
- Position
- 112,418,351–112,509,918 (+)
- Aliases
- BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
- Ensembl
- ENSG00000179295
- RefSeq RNA
- NM_001330437.2, NM_001374625.1, NM_002834.5, NM_018508.1, NM_080601.3
- RefSeq protein
- NP_001317366.1, NP_001361554.1, NP_002825.3, NP_542168.1, XP_011536915.1
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
protein tyrosine phosphatase non-receptor type 11
- Symbol
- PTPN11
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:112,418,351-112,509,918
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Shp-2.JPG
Show 8 more facts
- HomoloGene ID
- 2122
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5781
- genomic end
- 112509918
- genomic start
- 112856155
- chromosome
- human chromosome 12
- cytogenetic location
- 12q24.13
- genetic association
- metachondromatosis
Sources (7)
via Wikidata · CC0
~8 min read
Encyclopedic overview
13 sectionsContents
- Structure
- Function
- Clinical significance
- Noonan syndrome
- [[Noonan syndrome with multiple lentigines]]
- Metachondromatosis
- Cancer
- H Pylori CagA virulence factor
- Interactions
- Ligands
- References
- Further reading
- External links
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.
PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Excerpted from Wikipedia’s “PTPN11” article, available under the CC BY-SA 4.0 licence.