PTPN11
Sign in to saveAlso known as BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.
Gene data
PTPN11- Name
- protein tyrosine phosphatase non-receptor type 11
- Type
- protein-coding
- Position
- 112,418,351–112,509,918 (+)
- Aliases
- BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
- Ensembl
- ENSG00000179295
- RefSeq RNA
- NM_001330437.2, NM_001374625.1, NM_002834.5, NM_018508.1, NM_080601.3
- RefSeq protein
- NP_001317366.1, NP_001361554.1, NP_002825.3, NP_542168.1, XP_011536915.1
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
protein tyrosine phosphatase non-receptor type 11
- Symbol
- PTPN11
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:112,418,351-112,509,918
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~8 min read
Encyclopedic overview
13 sectionsContents
- Structure
- Function
- Clinical significance
- Noonan syndrome
- [[Noonan syndrome with multiple lentigines]]
- Metachondromatosis
- Cancer
- H Pylori CagA virulence factor
- Interactions
- Ligands
- References
- Further reading
- External links
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.
PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Excerpted from Wikipedia’s “PTPN11” article, available under the CC BY-SA 4.0 licence.