DUSP10
Sign in to saveAlso known as MKP-5, MKP5, dual specificity phosphatase 10
Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.
Gene data
DUSP10- Name
- dual specificity phosphatase 10
- Type
- protein-coding
- Position
- 221,700,666–221,743,169 (−)
- Aliases
- MKP-5, MKP5
- Ensembl
- ENSG00000143507
- RefSeq RNA
- NM_007207.6, NM_144728.2, NM_144729.2, NR_111939.2, NR_111940.2
- RefSeq protein
- NP_009138.1, XP_016855636.1, XP_047298898.1, XP_047298904.1, XP_054189977.1
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.
Excerpted from Wikipedia’s “DUSP10” article, available under the CC BY-SA 4.0 licence.