CEMIP

Also known as CCSP1, KIAA1199, TMEM2L, HYBID, cell migration inducing hyaluronan binding protein, cell migration inducing hyaluronidase 1

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene. CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases. Such function has also been validated in mice.

Gene data

CEMIP

Name: cell migration inducing hyaluronidase 1
Type: protein-coding
Position: 80,779,343–80,951,776 (+)
Aliases: CCSP1, CEMIP1, HYBID, KIAA1199, TMEM2L
Ensembl: ENSG00000103888
RefSeq RNA: NM_001293298.2, NM_001293304.2, NM_018689.3, XM_047432893.1, XM_047432894.1
RefSeq protein: NP_001280227.1, NP_001280233.1, NP_061159.1, XP_047288849.1, XP_047288850.1

Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of transport. Located in clathrin-coated endocytic vesicle; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]