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GeneQ18043110· pop 6· linked from 43 articles

RPTOR

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Also known as KOG1, Mip1, regulatory associated protein of MTOR complex 1

Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an adapter protein that is encoded in humans by the RPTOR gene. Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.

Gene data

RPTOR
Name
regulatory associated protein of MTOR complex 1
Type
protein-coding
Position
80,544,819–80,966,371 (+)
Aliases
KOG1, Mip1
Ensembl
ENSG00000141564
RefSeq RNA
NM_001163034.2, NM_020761.3
RefSeq protein
NP_001156506.1, NP_065812.1

This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Gene Ontology

Pathways

Autophagy - other - Homo sapiens (human)Autophagy - animal - Homo sapiens (human)mTOR signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)AMPK signaling pathway - Homo sapiens (human)Longevity regulating pathway - Homo sapiens (human)Longevity regulating pathway - multiple species - Homo sapiens (human)Thermogenesis - Homo sapiens (human)Insulin signaling pathway - Homo sapiens (human)Shigellosis - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

regulatory associated protein of MTOR complex 1

Symbol
RPTOR
Biotype
Protein coding
Organism
Homo sapiens
Location
17:80,544,819-80,966,371
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~6 min read

Encyclopedic overview

11 sections
Contents
  • Gene and expression
  • Location
  • Function
  • Structure
  • Interactions
  • Clinical significance
  • Signaling in cancer
  • As a drug target
  • See also
  • References
  • Further reading

Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an adapter protein that is encoded in humans by the RPTOR gene. Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.

==Gene and expression==

Excerpted from Wikipedia’s “RPTOR” article, available under the CC BY-SA 4.0 licence.

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