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GeneQ18045815· pop 6· linked from 78 articles

CENPH

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Also known as centromere protein H

Centromere protein H is a protein that in humans is encoded by the CENPH gene. It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.

Gene data

CENPH
Name
centromere protein H
Type
protein-coding
Position
69,189,537–69,210,357 (+)
Ensembl
ENSG00000153044
RefSeq RNA
NM_022909.4
RefSeq protein
NP_075060.1

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Amplification of signal from the kinetochoresAmplification of signal from unattached kinetochores via a MAD2 inhibitory signalSignal TransductionCell CycleSignaling by Rho GTPasesRHO GTPase EffectorsSeparation of Sister ChromatidsResolution of Sister Chromatid CohesionMitotic Metaphase and AnaphaseRHO GTPases Activate Formins

via MyGene.info

Gene · Ensembl

centromere protein H

Symbol
CENPH
Biotype
Protein coding
Organism
Homo sapiens
Location
5:69,189,537-69,210,357
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
32519
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/64946
genomic end
68506184
genomic start
69189574
chromosome
human chromosome 5
cytogenetic location
5q13.2
expressed in
Achilles tendon
Sources (4)

via Wikidata · CC0

~2 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • Interactions
  • References
  • External links
  • Further reading

Centromere protein H is a protein that in humans is encoded by the CENPH gene. It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.

== Function ==

Excerpted from Wikipedia’s “CENPH” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0