Structure via PubChem · Public domain (PubChem)
cephacetrile
Sign in to saveAlso known as Vetrimast [veterinary], Cefacetrilo, Cefacetrilum, Cefacetrile, Celospor, Celtol
Cefacetrile (INN, also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in gram-positive and gram-negative bacterial infections. It is a bacteriostatic antibiotic. Cefacetrile is marketed under the trade names Celospor, Celtol, and Cristacef, and as Vetimast for the treatment of mammary infections in lactating cows. ==Synthesis== thumb|center|500px|Cefacetrile synthesis: (1966 to Ciba-Geigy). It was made by reacting 7-ACA (7-aminocephalosporanic acid) with cyanoacetyl chloride in the presence of tributylamine.
Chemical data
- Formula
- C13H13N3O6S
- Molecular weight
- 339.33 g/mol
- IUPAC name
- (6R,7R)-3-(acetyloxymethyl)-7-[(2-cyanoacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- bacterial disease
via ChEMBL · EBI
Research
16,738 papers- Enteric (typhoid and paratyphoid) fever.Lancet (London, England) · 2025
- Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study.Lancet (London, England) · 2025
- Limited impact of Salmonella stress and persisters on antibiotic clearance.Nature · 2025
- The 2024 European guideline on the management of epididymo-orchitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
- How accurate is ceftriaxone at predicting susceptibility of enterobacterales isolates to oral higher-generation cephalosporins?Antimicrobial agents and chemotherapy · 2025
via PubMed
Wikidata facts
- Mass
- 339.052506
Show 3 more facts
- chemical formula
- C₁₃H₁₃N₃O₆S
- canonical SMILES
- CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)CC#N)SC1)C(=O)O
- isomeric SMILES
- CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)CC#N)SC1)C(=O)O
Sources (2)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- Synthesis
- References
Cefacetrile (INN, also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in gram-positive and gram-negative bacterial infections. It is a bacteriostatic antibiotic. Cefacetrile is marketed under the trade names Celospor, Celtol, and Cristacef, and as Vetimast for the treatment of mammary infections in lactating cows. ==Synthesis== thumb|center|500px|Cefacetrile synthesis: (1966 to Ciba-Geigy). It was made by reacting 7-ACA (7-aminocephalosporanic acid) with cyanoacetyl chloride in the presence of tributylamine.
== References ==
Gallery (2)
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via Wikidata sitelinks · CC0