cephacetrile
Sign in to saveCefacetrile (INN, also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in gram-positive and gram-negative bacterial infections. It is a bacteriostatic antibiotic. Cefacetrile is marketed under the trade names Celospor, Celtol, and Cristacef, and as Vetimast for the treatment of mammary infections in lactating cows. ==Synthesis== thumb|center|500px|Cefacetrile synthesis: (1966 to Ciba-Geigy). It was made by reacting 7-ACA (7-aminocephalosporanic acid) with cyanoacetyl chloride in the presence of tributylamine.
Chemical data
- Formula
- C13H13N3O6S
- Molecular weight
- 339.33 g/mol
- IUPAC name
- (6R,7R)-3-(acetyloxymethyl)-7-[(2-cyanoacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
via PubChem
Research
16,738 papers- Enteric (typhoid and paratyphoid) fever.Lancet (London, England) · 2025
- Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study.Lancet (London, England) · 2025
- Limited impact of Salmonella stress and persisters on antibiotic clearance.Nature · 2025
- The 2024 European guideline on the management of epididymo-orchitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
- How accurate is ceftriaxone at predicting susceptibility of enterobacterales isolates to oral higher-generation cephalosporins?Antimicrobial agents and chemotherapy · 2025
via PubMed
Article
2 sectionsContents
- Synthesis
- References
Cefacetrile (INN, also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in gram-positive and gram-negative bacterial infections. It is a bacteriostatic antibiotic. Cefacetrile is marketed under the trade names Celospor, Celtol, and Cristacef, and as Vetimast for the treatment of mammary infections in lactating cows. ==Synthesis== thumb|center|500px|Cefacetrile synthesis: (1966 to Ciba-Geigy). It was made by reacting 7-ACA (7-aminocephalosporanic acid) with cyanoacetyl chloride in the presence of tributylamine.
== References ==