cerberin
Sign in to saveAlso known as 3beta-O-(L-2'-O-acetylthevetosyl)-14beta-hydroxy-5beta-card-20(22)-enolide, 2'-Acetylneriifolin
Cerberin is a type of cardiac glycoside found in the seeds of trees in the genus Cerbera, including the suicide tree (Cerbera odollam) and the sea mango (Cerbera manghas). As a cardiac glycoside, cerberin disrupts the function of the heart by blocking its sodium and potassium ATPase. Cerberin can be used as a treatment for heart failure and arrhythmia.
Wikidata facts
- Mass
- 576.33
Show 3 more facts
- canonical SMILES
- CC1C(C(C(C(O1)OC2CCC3(C(C2)CCC4C3CCC5(C4(CCC5C6=CC(=O)OC6)O)C)C)OC(=O)C)OC)O
- chemical formula
- C₃₂H₄₈O₉
- isomeric SMILES
- C[C@H]1[C@@H]([C@H]([C@@H]([C@@H](O1)O[C@H]2CC[C@]3([C@@H](C2)CC[C@@H]4[C@@H]3CC[C@]5([C@@]4(CC[C@@H]5C6=CC(=O)OC6)O)C)C)OC(=O)C)OC)O
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Article
14 sectionsContents
- Structure and properties
- Structure
- Physical properties
- Toxicity
- Symptoms
- Poisonings
- Mechanism of action
- Na<sup>+</sup>/K<sup>+</sup>-ATPase pump
- Na<sup>+</sup>/Ca<sup>2+</sup>-exchanger
- Metabolism
- Efficacy
- Therapeutic uses
- Further reading
- References
Cerberin is a type of cardiac glycoside found in the seeds of trees in the genus Cerbera, including the suicide tree (Cerbera odollam) and the sea mango (Cerbera manghas). As a cardiac glycoside, cerberin disrupts the function of the heart by blocking its sodium and potassium ATPase. Cerberin can be used as a treatment for heart failure and arrhythmia.
Overconsumption of cerberin results in poisoning. Symptoms include nausea, vomiting, and bradycardia, often leading to death. Cerberin-containing plants such as Cerbera odollam have historically been used for suicide and homicide in their native regions due to their high toxicity.