cholangiocarcinoma

Also known as adult primary cholangiocellular carcinoma, cholangiosarcoma, bile duct cancer, cancer of the bile duct, adult primary Cholangiocarcinoma

Key facts

Medical condition.name: Cholangiocarcinoma
Medical condition.synonyms: Bile duct cancer, cancer of the bile duct
Medical condition.image: Cholangiocarcinoma - very high mag.jpg
Medical condition.caption: Micrograph of an intrahepatic cholangiocarcinoma (right of image) adjacent to normal liver cells (left of image). H&E stain.
Medical condition.field: Oncology
Medical condition.symptoms: Abdominal pain, yellowish skin, weight loss, generalized itching, fever
Medical condition.onset: 70 years old
Medical condition.types: Intrahepatic, perihilar, distal
Medical condition.risks: Primary sclerosing cholangitis, ulcerative colitis, smoking, heavy alcohol use, infection with certain liver flukes, some congenital liver malformations
Medical condition.diagnosis: Confirmed by examination of the tumor under a microscope
Medical condition.treatment: Surgical resection, chemotherapy, radiation therapy, stenting procedures, liver transplantation
Medical condition.prognosis: Generally poor
Medical condition.frequency: 1–2 people per 100,000 per year (Western world)

via Wikipedia infobox

Research

25,808 papers

Cholangiocarcinoma.Lancet (London, England) · 2014
Anatomical, histomorphological and molecular classification of cholangiocarcinoma.Liver international : official journal of the International Association for the Study of the Liver · 2019
Current epidemiology of cholangiocarcinoma in Western countries.Journal of hepatology · 2022
[Cholangiocarcinoma].Praxis · 2002
Cholangiocarcinoma: Molecular Abnormalities and Cells of Origin.Technology in cancer research & treatment · 2023

via PubMed

Wikidata facts

Subclass of: disease
Image: Cholangiocarcinoma.png

Show 6 more facts

Commons category: Cholangiocarcinoma
NCI Thesaurus ID: C4436
health specialty: oncology
drug or therapy used for treatment: regorafenib
exact match: identifiers.org/doid/DOID:4947
on focus list of Wikimedia project: WikiProject Medicine

Sources (6)

via Wikidata · CC0

~21 min read

Encyclopedic overview

17 sections

Contents

Signs and symptoms
Risk factors
Pathophysiology
Diagnosis
Blood tests
Abdominal imaging
Imaging of the biliary tree
Surgery
Pathology
Staging
Treatment
Adjuvant chemotherapy and radiation therapy
Treatment of advanced disease
Prognosis
Epidemiology
References
External links

Cholangiocarcinoma, also known as bile duct cancer, is a type of cancer that forms in the bile ducts. Symptoms of cholangiocarcinoma may include abdominal pain, yellowish skin, weight loss, generalized itching, and fever. Light colored stool or dark urine may also occur. Other biliary tract cancers include gallbladder cancer and cancer of the ampulla of Vater.

Risk factors for cholangiocarcinoma include primary sclerosing cholangitis (an inflammatory disease of the bile ducts), ulcerative colitis, cirrhosis, hepatitis C, hepatitis B, infection with certain liver flukes, and some congenital liver malformations. Most people have no identifiable risk factors. The diagnosis is suspected based on a combination of blood tests, medical imaging, endoscopy, and sometimes surgical exploration. The disease is confirmed by examination of cells from the tumor under a microscope. It is typically an adenocarcinoma (a cancer that forms glands or secretes mucin).

Excerpted from Wikipedia’s “cholangiocarcinoma” article, available under the CC BY-SA 4.0 licence.