CHRNA1
Sign in to saveAlso known as ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, CMS1A, CMS1B
Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAChR).
Gene data
CHRNA1- Name
- cholinergic receptor nicotinic alpha 1 subunit
- Type
- protein-coding
- Position
- 174,747,592–174,787,935 (−)
- Aliases
- ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS
- Ensembl
- ENSG00000138435
- RefSeq RNA
- NM_000079.4, NM_001039523.3, NM_001445681.1, NM_001445683.1, NM_001445684.1
- RefSeq protein
- NP_000070.1, NP_001034612.1, NP_001432610.1, NP_001432612.1, NP_001432613.1
The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cholinergic receptor nicotinic alpha 1 subunit
- Symbol
- CHRNA1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:174,747,592-174,787,935
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
166 papers- CHRNA1 induces sarcopenia through neuromuscular synaptic elimination.Experimental gerontology · 2022
- CHRNA1 promotes the pathogenesis of primary focal hyperhidrosis.Molecular and cellular neurosciences · 2021
- Congenital Myasthenic Syndromes Overview.1993
- CHRNA1 and its correlated-myogenesis/cell cycle genes are prognosis-related markers of metastatic melanoma.Biochemistry and biophysics reports · 2023
- Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis.Annals of clinical and translational neurology · 2022
via PubMed
~1 min read
Encyclopedic overview
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAChR).
The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, delta and epsilon subunits. The gamma sub-unit being only present in embryonic nAChR. This gene encodes an alpha subunit that plays a role in acetylcholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.
Excerpted from Wikipedia’s “CHRNA1” article, available under the CC BY-SA 4.0 licence.