GRIN1
Sign in to saveAlso known as GluN1, MRD8, NMDA1, NMDAR1, NR1, NMD-R1, glutamate ionotropic receptor NMDA type subunit 1, NDHMSR
Glutamate Receptor Ionotropic, [NMDA] subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene.
Gene data
GRIN1- Name
- glutamate ionotropic receptor NMDA type subunit 1
- Type
- protein-coding
- Position
- 137,138,346–137,168,756 (+)
- Aliases
- DEE101, GluN1, MRD8, NDHMSD, NDHMSR, NMD-R1, NMDA1, NMDAR1, NR1, hNR1
- Ensembl
- ENSG00000176884
- RefSeq RNA
- NM_000832.7, NM_001185090.2, NM_001185091.2, NM_001437330.1, NM_001437331.1
- RefSeq protein
- NP_000823.4, NP_001172019.1, NP_001172020.1, NP_001424259.1, NP_001424260.1
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- PDB 2nr1 EBI.jpg
Show 5 more facts
- HomoloGene ID
- 7187
- exact match
- identifiers.org/ncbigene/2902
- genomic end
- 137168756
- genomic start
- 137139154
- cytogenetic location
- 9q34.3
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Article
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- See also
- References
- Further reading
Glutamate Receptor Ionotropic, [NMDA] subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene.
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. The sequence of exon 5 is identical in vertebrates, with exon 5 splicing demonstrated in human, mouse and rat. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.