POLR2M
Sign in to saveAlso known as GCOM1, GRINL1A, Gdown, Gdown1, polymerase (RNA) II subunit M, RNA polymerase II subunit M
GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene.
Gene data
POLR2M- Name
- RNA polymerase II subunit M
- Type
- protein-coding
- Position
- 57,706,641–57,782,762 (+)
- Aliases
- GRINL1A, Gdown, Gdown1
- Ensembl
- ENSG00000255529
- RefSeq RNA
- NM_001018102.3, NM_015532.5, NR_027390.1
- RefSeq protein
- NP_001018112.1, NP_056347.1
This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013].
Gene Ontology
Biological process
via MyGene.info
Gene · Ensembl
RNA polymerase II subunit M
- Symbol
- POLR2M
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:57,706,641-57,782,762
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 9181
- exact match
- identifiers.org/ncbigene/81488
- found in taxon
- Homo sapiens
- genomic end
- 58074960
- genomic start
- 57706695
- chromosome
- human chromosome 15
- cytogenetic location
- 15q21.3
- expressed in
- biceps brachii
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene.
This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants.
Excerpted from Wikipedia’s “POLR2M” article, available under the CC BY-SA 4.0 licence.