POLR2M

Also known as GCOM1, GRINL1A, Gdown, Gdown1, polymerase (RNA) II subunit M, RNA polymerase II subunit M

GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene.

Gene data

POLR2M

Name: RNA polymerase II subunit M
Type: protein-coding
Aliases: GRINL1A, Gdown, Gdown1

This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013].

via MyGene.info

Gene · Ensembl

RNA polymerase II subunit M

Symbol: POLR2M
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:57,706,641-57,782,762
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 9181
exact match: identifiers.org/ncbigene/81488
genomic end: 58074960
genomic start: 57706695
cytogenetic location: 15q21.3

Sources (4)

via Wikidata · CC0

~1 min read

Article

4 sections

Contents

See also
References
Further reading
External links

GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene.

This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants.