CLEC7A

Also known as BGR, CANDF4, CLECSF12, DECTIN1, CD369, SCARE2, C-type lectin domain family 7 member A, C-type lectin domain containing 7A

Gen der Spezies Homo sapiens

Gene data

CLEC7A

Name: C-type lectin domain containing 7A
Type: protein-coding
Position: 10,116,766–10,130,269 (−)
Aliases: BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2
Ensembl: ENSG00000172243
RefSeq RNA: NM_022570.5, NM_197947.3, NM_197948.3, NM_197949.3, NM_197950.3
RefSeq protein: NP_072092.2, NP_922938.1, NP_922939.1, NP_922940.1, NP_922941.1

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008].