COG5
Sign in to saveAlso known as CDG2I, GOLTC1, GTC90, component of oligomeric golgi complex 5
Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.
Gene data
COG5- Name
- component of oligomeric golgi complex 5
- Type
- protein-coding
- Position
- 107,198,800–107,564,515 (−)
- Aliases
- CDG2I, GOLTC1, GTC90
- Ensembl
- ENSG00000284369
- RefSeq RNA
- NM_001161520.2, NM_001379511.1, NM_001379512.1, NM_001379513.1, NM_001379514.1
- RefSeq protein
- NP_001154992.2, NP_001366440.1, NP_001366441.1, NP_001366442.1, NP_001366443.1
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
component of oligomeric golgi complex 5
- Symbol
- COG5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:107,198,800-107,564,515
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 42221
- genetic association
- osteoarthritis
- exact match
- identifiers.org/ncbigene/10466
- genomic start
- 106842000
- found in taxon
- Homo sapiens
- genomic end
- 107204959
- chromosome
- human chromosome 7
- cytogenetic location
- 7q22.3
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.
Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002).[supplied by OMIM]
Excerpted from Wikipedia’s “COG5” article, available under the CC BY-SA 4.0 licence.