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GeneQ18048581· pop 6· linked from 27 articles

COG7

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Also known as CDG2E, component of oligomeric golgi complex 7

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.

Gene data

COG7
Name
component of oligomeric golgi complex 7
Type
protein-coding
Position
23,388,493–23,453,210 (−)
Aliases
CDG2E
Ensembl
ENSG00000168434
RefSeq RNA
NM_153603.4, XM_017023870.2, XM_054314338.1
RefSeq protein
NP_705831.1, XP_016879359.1, XP_054170313.1

The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010].

Gene Ontology

Molecular function

protein binding

Pathways

ER to Golgi Anterograde TransportMembrane TraffickingMetabolism of proteinsAsparagine N-linked glycosylationVesicle-mediated transportPost-translational protein modificationCOPI-mediated anterograde transportIntra-Golgi trafficRetrograde transport at the Trans-Golgi-NetworkIntra-Golgi and retrograde Golgi-to-ER traffic

via MyGene.info

Gene · Ensembl

component of oligomeric golgi complex 7

Symbol
COG7
Biotype
Protein coding
Organism
Homo sapiens
Location
16:23,388,493-23,453,210
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
33431
genomic start
23388493
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/91949
genomic end
23453189
chromosome
human chromosome 16
cytogenetic location
16p12.2
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections
Contents
  • Interactions
  • References
  • Further reading
  • External links

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).[supplied by OMIM]

Excerpted from Wikipedia’s “COG7” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0