COMP
Sign in to saveAlso known as EPD1, MED, EDM1, PSACH, THBS5, cartilage oligomeric matrix protein, TSP5, CTS2
Genen från arten Homo sapiens
In the Vinony graph
Vinony's link graph records 109 inbound references to COMP, and connects out to PubMed, elastin and Ensembl genome database project.
It is catalogued under topics including Extracellular matrix proteins, Genes on human chromosome 19 and Thrombospondins.
Vinony links it to 5 Wikipedia language editions.
Gene data
COMP- Name
- cartilage oligomeric matrix protein
- Type
- protein-coding
- Position
- 18,782,773–18,791,312 (−)
- Aliases
- CTS2, EDM1, EPD1, MED, PSACH, THBS5, TSP-5, TSP5
- Ensembl
- ENSG00000105664
- RefSeq RNA
- NM_000095.3
- RefSeq protein
- NP_000086.2
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cartilage oligomeric matrix protein
- Symbol
- COMP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:18,782,773-18,791,312
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein COMP PDB 1fbm.png
Show 9 more facts
- HomoloGene ID
- 74
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1311
- genomic end
- 18791305
- genomic start
- 18893583
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.11
- genetic association
- pseudoachondroplasia
- expressed in
- ascending aorta
Sources (7)
via Wikidata · CC0