connectome
Sign in to savethumb|Nerve tract|White matter tracts within a human brain, as visualized by [[MRI tractography]] thumb|Rendering of a group connectome based on 20 subjects. Anatomical fibers that constitute the white matter architecture of the human brain are visualized color-coded by traversing direction (xyz-directions mapping to RGB colors respectively). Visualization of fibers was done using TrackVis software.
Article
18 sectionsContents
- Types of connectomes
- Macroscale
- Initial attempts at connectivity mapping
- Challenge for macroscale connectomics
- Chemical connectome
- Microscale (neural) connectome
- Alternatives to EM for detailed connectomes
- Plasticity of the connectome
- Pathology
- Model organisms and datasets
- Human
- Small animals
- Fruit fly
- Mouse
- Eyewire game
- See also
- References
- External links
thumb|Nerve tract|White matter tracts within a human brain, as visualized by [[MRI tractography]] thumb|Rendering of a group connectome based on 20 subjects. Anatomical fibers that constitute the white matter architecture of the human brain are visualized color-coded by traversing direction (xyz-directions mapping to RGB colors respectively). Visualization of fibers was done using TrackVis software.
A connectome () is a comprehensive map of neural connections in the brain, and may be thought of as its "wiring diagram". These maps are available in varying levels of detail. A functional connectome shows connections between various brain regions, but not individual neurons. These are available for large animals, including mice and humans, are normally obtained by techniques such as MRI, and have a scale of millimeters. At the other extreme are neural connectomes, which show individual neurons and their interconnections. These are usually obtained by electron microscopy (EM) and have a scale of nanometers. They are only available for small creatures such as the worm C. elegans and the fruit fly Drosophila melanogaster, and small regions of mammal brains. Finally there are chemical connectomes, showing which neurons emit, and are sensitive to, a wide variety of neuromodulators. As of 2025, only C. elegans has such a connectome.