costamere
Sign in to saveAlso known as GO:0043034, costameres
The costamere is a structural-functional component of striated muscle cells which connects the sarcomere of the muscle to the cell membrane (i.e. the sarcolemma).
Research
344 papers- Costamere proteins and their involvement in myopathic processes.Expert reviews in molecular medicine · 2015
- Master Regulators of Muscle Atrophy: Role of Costamere Components.Cells · 2021
- Vinculin haploinsufficiency impairs integrin-mediated costamere remodeling on stiffer microenvironments.Journal of molecular and cellular cardiology · 2025
- Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2019
- Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle.Cellular and molecular life sciences : CMLS · 2014
via PubMed
Wikidata facts
- Part of
- myofibril
Show 1 more fact
- exact match
- purl.obolibrary.org/obo/GO_0043034
Sources (1)
via Wikidata · CC0
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Encyclopedic overview
5 sectionsContents
- Structure
- Function
- Pathology
- Dynamics
- References
The costamere is a structural-functional component of striated muscle cells which connects the sarcomere of the muscle to the cell membrane (i.e. the sarcolemma).
Costameres are sub-sarcolemmal protein assemblies circumferentially aligned in register with the Z-disk of peripheral myofibrils. They physically couple force-generating sarcomeres with the sarcolemma in striated muscle cells and are thus considered one of several "Achilles' heels" of skeletal muscle, a critical component of striated muscle morphology which, when compromised, is thought to directly contribute to the development of several distinct myopathies.
Excerpted from Wikipedia’s “costamere” article, available under the CC BY-SA 4.0 licence.