Dystroglycan 1
Sign in to saveAlso known as dystroglycan 1 (dystrophin-associated glycoprotein 1), DAG1, dystroglycan, Dystrophin-associated glycoprotein 1
Dystroglycan is a protein that in humans is encoded by the DAG1 gene.
Protein · UniProt
Dystroglycan 1
- Gene
- DAG1
- Organism
- Homo sapiens (Human)
- Length
- 895 aa
- Molecular mass
- 97,441 Da
- Evidence
- 1: Evidence at protein level
The dystroglycan complex is involved in a number of signaling events and processes including laminin deposition and extracellular matrix assembly, acetylcholine receptor clustering, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, epithelial polarization, and epithelium branching morphogenesis (By similarity). Required for the formation of photoreceptor ribbon synapses, and long-term maintenance of inhibitory synapses in cerebellar Purkinje cells (By similarity). Also involved in the positive regulation of cartilage formation through agrin…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
3 registered- PHASE1COMPLETEDIntravenous Immune Globulin to Treat Hereditary Inclusion Body MyopathyNational Human Genome Research Institute (NHGRI) · NCT00195637
- RECRUITINGClinical Trial Readiness for the DystroglycanopathiesKatherine Mathews · NCT00313677
- RECRUITINGCongenital Muscle Disease Study of Patient and Family Reported Medical InformationCure CMD · NCT01403402
Wikidata facts
- Instance of
- protein
Show 2 more facts
- P352
- Savoy
- found in taxon
- Homo sapiens
via Wikidata · CC0
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Encyclopedic overview
7 sectionsContents
- Function
- Expression
- Interactions
- See also
- References
- Further reading
- External links
Dystroglycan is a protein that in humans is encoded by the DAG1 gene.
Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in Homo sapiens on chromosome 3. There are two exons that are separated by a large intron. The spliced exons code for a protein product that is finally cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal).
Excerpted from Wikipedia’s “Dystroglycan 1” article, available under the CC BY-SA 4.0 licence.