troponin complex
Sign in to saveTroponin, or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that are integral to muscle contraction in skeletal muscle and cardiac muscle, but not smooth muscle. Measurements of cardiac-specific troponins I and T are extensively used as diagnostic and prognostic indicators in the management of myocarditis, myocardial infarction and acute coronary syndrome. Blood levels of cardiac troponin (cTn) may be used as a diagnostic marker for stroke or other myocardial injury that is ongoing, although the sensitivity of this measurement is low.
Key facts
- Diagnostic.name
- Cardiac troponin I/T in serum
- Diagnostic.image
- Troponin Ribbon Diagram.png
- Diagnostic.caption
- Ribbon representation of the human cardiac troponin core complex (52 kDa core) in the calcium-saturated form. Blue = troponin C; green = troponin I; magenta = troponin T.
- Diagnostic.purpose
- Detect heart damage
- Diagnostic.synonyms
- "troponin" (vague)
via Wikipedia infobox
Article
19 sectionsContents
- Function
- Physiology
- Paralogs
- Use in diagnostics
- Detection
- cTnI/T as biomarkers
- Cardiac conditions
- Non-cardiac conditions
- Hypertension
- Toxicity
- Lung
- Kidney
- Skeletal muscle
- COVID-19
- Prognostic use
- Evolution
- See also
- References
- External links
Troponin, or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that are integral to muscle contraction in skeletal muscle and cardiac muscle, but not smooth muscle. Measurements of cardiac-specific troponins I and T are extensively used as diagnostic and prognostic indicators in the management of myocarditis, myocardial infarction and acute coronary syndrome. Blood levels of cardiac troponin (cTn) may be used as a diagnostic marker for stroke or other myocardial injury that is ongoing, although the sensitivity of this measurement is low.
==Function== Troponin is attached to the protein tropomyosin and lies within the groove between actin filaments in muscle tissue. In a relaxed muscle, tropomyosin blocks the attachment site for the myosin crossbridge, thus preventing contraction. When the muscle cell is stimulated to contract by an action potential, calcium channels open in the sarcoplasmic membrane and release calcium into the sarcoplasm. Some of this calcium attaches to troponin, which causes it to change shape, exposing binding sites for myosin (active sites) on the actin filaments. Myosin's binding to actin causes crossbridge formation, and contraction of the muscle begins.