CTCF

Name

CCCTC-binding factor

Type

protein-coding

Position

67,561,831–67,639,189 (+)

Aliases

CFAP108, FAP108, MRD21

Ensembl

ENSG00000102974

RefSeq RNA

NM_001191022.2, NM_001363916.2, NM_001438968.1, NM_001438969.1, NM_006565.4

RefSeq protein

NP_001177951.1, NP_001350845.1, NP_001425897.1, NP_001425898.1, NP_006556.1

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

via MyGene.info

Gene · Ensembl

CCCTC-binding factor

Symbol

CTCF

Biotype

Protein coding

Organism

Homo sapiens

Location

16:67,561,831-67,639,189

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein CTCF PDB 1x6h.png

via Wikidata · CC0