CTD phosphatase subunit 1

Also known as CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1, TFIIF-associating CTD phosphatase, TFIIF-associating CTD phosphatase 1, CTD of POLR2A, phosphatase of, subunit 1, RNA polymerase II subunit A C-terminal domain phosphatase, transcription factor IIF-associating CTD phosphatase 1, CTDP1, serine phosphatase FCP1a

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.

In the Vinony graph

Within Vinony's link graph, CTD phosphatase subunit 1 is referenced by 8 other articles, and connects out to PubMed, human chromosome 18 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 18.

Its subject is documented across 5 Wikipedia language editions.

Protein · UniProt

RNA polymerase II subunit A C-terminal domain phosphatase

Gene: CTDP1
Organism: Homo sapiens (Human)
Length: 961 aa
Molecular mass: 104,399 Da
Evidence: 1: Evidence at protein level

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation

3D-structureAcetylationAlternative splicingCataractCell cycleCell divisionCytoplasmCytoskeleton

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Swiss-Prot (reviewed) · via UniProt

Wikidata facts

Instance of: protein

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found in taxon: Homo sapiens

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Encyclopedic overview

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RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.

This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.

Excerpted from Wikipedia’s “CTD phosphatase subunit 1” article, available under the CC BY-SA 4.0 licence.